Title :
A novel ultrasonic resonance spectrometer for microbubble sizing
Author :
Schmitt, Rainer M. ; Schmidt, H.J. ; Kripfgans, Oliver ; Poser, C.
Author_Institution :
Dept. of Ultrasound, Fraunhofer Inst. for Biomed. Eng., St. Ingbert, Germany
Abstract :
A method and system for in vitro estimation of the diameter distribution in an ensemble for microbubbles is described. The system is based on the two-frequency insonification method and allows rapid (<1 s) distribution estimates in the range of ⩾1 μm and bubble lifetime measurements. Attenuation backscatter and velocity measurements can be performed in the same sample volume. The system is designed as a tool for the development of ultrasonic contrast agents
Keywords :
biomedical equipment; biomedical measurement; biomedical ultrasonics; bubbles; diameter measurement; particle size measurement; ultrasonic transducers; attenuation backscatter; bubble lifetime measurements; contrast echocardiography; diameter distribution; imaging transducer; in vitro estimation; microbubble sizing; pumping wave transducer; scattered wave receiving transducer; two-frequency insonification method; ultrasonic contrast agents; ultrasonic resonance spectrometer; velocity measurements; Backscatter; Biomedical engineering; Biomembranes; In vitro; Nonlinear equations; Resonance; Spectroscopy; Surface tension; Time measurement; Velocity measurement;
Conference_Titel :
Ultrasonics Symposium, 1992. Proceedings., IEEE 1992
Conference_Location :
Tucson, AZ
Print_ISBN :
0-7803-0562-0
DOI :
10.1109/ULTSYM.1992.275821
