A novel ultrasonic resonance spectrometer for microbubble sizing

Author

Schmitt, Rainer M. ; Schmidt, H.J. ; Kripfgans, Oliver ; Poser, C.

Author_Institution

Dept. of Ultrasound, Fraunhofer Inst. for Biomed. Eng., St. Ingbert, Germany

fYear

1992

Firstpage

941

Abstract

A method and system for in vitro estimation of the diameter distribution in an ensemble for microbubbles is described. The system is based on the two-frequency insonification method and allows rapid (<1 s) distribution estimates in the range of ⩾1 μm and bubble lifetime measurements. Attenuation backscatter and velocity measurements can be performed in the same sample volume. The system is designed as a tool for the development of ultrasonic contrast agents

Keywords

biomedical equipment; biomedical measurement; biomedical ultrasonics; bubbles; diameter measurement; particle size measurement; ultrasonic transducers; attenuation backscatter; bubble lifetime measurements; contrast echocardiography; diameter distribution; imaging transducer; in vitro estimation; microbubble sizing; pumping wave transducer; scattered wave receiving transducer; two-frequency insonification method; ultrasonic contrast agents; ultrasonic resonance spectrometer; velocity measurements; Backscatter; Biomedical engineering; Biomembranes; In vitro; Nonlinear equations; Resonance; Spectroscopy; Surface tension; Time measurement; Velocity measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 1992. Proceedings., IEEE 1992

Conference_Location

Tucson, AZ

Print_ISBN

0-7803-0562-0

Type

conf

DOI

10.1109/ULTSYM.1992.275821

Filename

275821