Title :
In Situ Sensing and Manipulation in Nano Bio Systems
Author :
Xi, Ning ; Li, Guangyong ; Wang, Donna H.
Author_Institution :
Dept. of Electr. Eng., Michigan State Univ., East Lansing, MI
Abstract :
The goal of this article is to review the state-of-art techniques for characterizing specific single receptor using the functionalized AFM (atomic force microscopy) tip and introduce the progress of in situ probing biomolecules as well as the possibility of single cell surgery by AFM. An example of studying the angiotensin II type 1 (ATI) receptors expressed in sensory neuronal cells by AFM with a functionalized tip is given. Perspectives for identifying and characterizing specific individual membrane proteins using AFM in living cells are provided
Keywords :
atomic force microscopy; molecular biophysics; nanobiotechnology; proteins; surgery; angiotensin II type 1 receptors; atomic force microscopy; in situ probing biomolecules; in situ sensing; living cells; membrane proteins; nano bio systems; sensory neuronal cells; single cell surgery; Atomic force microscopy; Augmented reality; Biomembranes; Force sensors; High-resolution imaging; Molecular biophysics; Nanobioscience; Proteins; Surface topography; Virtual reality;
Conference_Titel :
Micro-NanoMechatronics and Human Science, 2006 International Symposium on
Conference_Location :
Nagoya
Print_ISBN :
1-4244-0717-6
Electronic_ISBN :
1-4244-0718-1
DOI :
10.1109/MHS.2006.320304
