Title :
Aminosilane-modified mesoporous oxidized silicon for in situ oligonucleotides synthesis and detection
Author :
Terracciano, Matthew ; De Stefano, L. ; Rendina, I. ; Oliviero, Giorgia ; Piccialli, Gennaro ; Borbone, Nicola ; Rea, I.
Author_Institution :
Inst. for Microelectron. & Microsyst., Nat. Council of Res., Italy
Abstract :
Direct solid phase of oligonucleotides (ONs) requires high chemical stability of the support material. In this work, we investigate the passivation ability of porous oxidized silicon multilayered structures by two aminosilane compounds, APTES and APDMES, for the realization of a label-free ON optical biosensor.
Keywords :
DNA; biochemistry; biosensors; electrochemical sensors; elemental semiconductors; mesoporous materials; molecular biophysics; multilayers; optical sensors; oxidation; passivation; silicon; Si; aminosilane compounds; aminosilane-modified mesoporous oxidized silicon; chemical stability; in situ oligonucleotides detection; in situ oligonucleotides synthesis; label-free ON optical biosensor; passivation; porous oxidized silicon multilayered structures; Bioinformatics; Biosensors; DNA; Genomics; Maximum likelihood estimation; Probes; Resists; DNA synthesis; functionalization; porous silicon; surface stability;
Conference_Titel :
Photonics Technologies, 2014 Fotonica AEIT Italian Conference on
Conference_Location :
Naples
Print_ISBN :
978-8-8872-3718-4
DOI :
10.1109/Fotonica.2014.6843946
