Title :
The Effect of ATP and P2X Receptor on Respiration in the Neunatal Rat Transverse Medullary Slice
Author :
Ning, Sui ; Ma, Yan ; Song, Na-Na ; Liu, Zi-Bing ; Li, Li ; Zhu, Da-Nian ; Shen, Lin-Lin
Author_Institution :
Dept. of Physiol., Fudan Univ., Shanghai
Abstract :
ATP has become widely recognized as a key mediator in both central and peripheral chemosensory transduction in adult rat. The distribution of P2X receptor subtype and the role of ATP in neonatal rat are unclear. The main objective of this study was to observe the role of ATP-mediated respiratory activity in the neonatal rat transverse medullary slice. The increase of respiratory activity was dose-dependent of ATP and via P2X receptors in the medulla of neonatal SD rats. The effect of ATP was reduced by P2X receptor blocker, Suramin or NF279. The inhibition of ATP-excited respiratory activity by NF279 appeared to be more significant than by Suramin.
Keywords :
chemioception; neurophysiology; organic compounds; pneumodynamics; ATP dose dependent respiratory activity; ATP effects; ATP mediated respiratory activity; NF279; P2X receptor effects; Suramin; central chemosensory transduction; neonatal rat transverse medullary slice; peripheral chemosensory transduction; respiration; Centralized control; Control systems; Educational institutions; Extracellular; Heart; Immune system; Neurons; Pediatrics; Physiology; Rats;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.258
