Electrochemical Approach to Pattern Cells within Three-Dimensional Microstructures

The ability to control of the behavior of living cells in vitro is critical in fundamental cell biology as well as applied biotechnology including tissue engineering and cell-based chip devices. Patterning cells on surfaces is one of the most important approaches to modulate cell behaviors and functions in culture. Here, we describe ongoing work on the newly developed surface patterning technique, "electrochemical bio-lithography", with a focus on the following two subjects: 1) patterning cells within preassembled microfluidic devices and 2) dynamic control of cellular motility