Self-assembled polyelectrolyte capsule for drug delivery: In vitro evaluation of their interaction with cell

Author

Maggi, Norbert ; Baroffio, Michele ; Pastorino, Laura ; Crimi, Stefano ; Folli, Chiara ; Brusasco, Vito ; Ruggiero, Carmelina

Author_Institution

Dept. of Inf., Bioeng., Robot. & Syst. Eng., Univ. of Genoa, Genoa, Italy

fYear

2014

fDate

18-21 Aug. 2014

Firstpage

521

Lastpage

524

Abstract

Polyelectrolyte capsules based on layer by layer self-assembly show great promise for targeted delivery and smart release of drugs. A critical aspect for their clinical use is the evaluation of the interaction capsules-cell. The present paper is focused on the in vitro characterization of such interaction by optical magnetic twisting cytometry (OMCT).

Keywords

biomedical materials; biomedical measurement; cellular transport; drug delivery systems; intelligent materials; materials preparation; nanofabrication; nanomedicine; polymer electrolytes; self-assembly; OMCT; capsule-cell interaction; drug delivery; in vitro characterization; in vitro evaluation; layer by layer self-assembly; optical magnetic twisting cytometry; polyelectrolyte capsules; self-assembled polyelectrolyte capsule; smart drug release; targeted delivery; Biomedical optical imaging; Calcium; Drugs; Magnetic fields; Proteins; Self-assembly; Torque;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology (IEEE-NANO), 2014 IEEE 14th International Conference on

Conference_Location

Toronto, ON

Type

conf

DOI

10.1109/NANO.2014.6968171

Filename

6968171