Title :
Design of a Novel Acid-Sensing Biosensor Based on Taste Neurons and LAPS
Author :
Peihua Chen ; Gong Cheng ; Bingqing Wang ; Ping Wang
Author_Institution :
Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou
Abstract :
A novel biosensor based on the platform of neuron- silicon interface was designed and characterized. Taste receptor cells cultured on light addressable potentiometric sensor (LAPS) can recognize sour stimuli as compared with non-acid solutions. A computational model of taste receptor cells was constructed to simulate the ionic currents and action potentials of taste receptor cells, to help decode extracellular signals recorded by LAPS. This study provides the prototype of a novel biosensor which deploys the sensory transduction and decoding mechanism from biology to realize chemosensing, potentially in a noninvasive and long- term manner.
Keywords :
biosensors; chemioception; potentiometers; acid sensing biosensor; action potentials; extracellular signals; ionic current; light addressable potentiometric sensor; sensory transduction; taste neurons; taste receptor cells; Biological system modeling; Biology computing; Biosensors; Cells (biology); Computational modeling; Decoding; Neurons; Sensor phenomena and characterization; Silicon; Taste buds;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.719
