Title :
An IC/microfluidic hybrid microsystem for 2D magnetic manipulation of individual biological cells
Author :
Lee, Hakho ; Liu, Yong ; Alsberg, Eben ; Ingber, Donald E. ; Westervelt, Robert M. ; Ham, Donhee
Author_Institution :
Harvard Univ., Cambridge, MA, USA
Abstract :
A microfluidic system is fabricated on top of an IC chip, suspending magnetic-bead-tagged biological cells in a biocompatible environment. The IC produces patterned magnetic fields using a microcoil array to manipulate individual bead-bound cells. The hybrid prototype manipulates bovine capillary endothelial cells with precise spatial control.
Keywords :
biomedical electronics; electromagnetic actuators; microfluidics; micromanipulators; 2D magnetic manipulation; IC/microfluidic hybrid microsystem; bead-bound cells; biocompatible environment; bovine capillary endothelial cells; individual biological cell manipulation; microcoil array; patterned magnetic fields; spatial cell control; suspending magnetic-bead-tagged biological cells; Biological cells; Hospitals; Hybrid integrated circuits; Magnetic fields; Magnetic levitation; Medical diagnosis; Medical diagnostic imaging; Microfluidics; Pediatrics; Spatial resolution;
Conference_Titel :
Solid-State Circuits Conference, 2005. Digest of Technical Papers. ISSCC. 2005 IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
0-7803-8904-2
DOI :
10.1109/ISSCC.2005.1493878
