An IC/microfluidic hybrid microsystem for 2D magnetic manipulation of individual biological cells

Author

Lee, Hakho ; Liu, Yong ; Alsberg, Eben ; Ingber, Donald E. ; Westervelt, Robert M. ; Ham, Donhee

Author_Institution

Harvard Univ., Cambridge, MA, USA

fYear

2005

Firstpage

80

Abstract

A microfluidic system is fabricated on top of an IC chip, suspending magnetic-bead-tagged biological cells in a biocompatible environment. The IC produces patterned magnetic fields using a microcoil array to manipulate individual bead-bound cells. The hybrid prototype manipulates bovine capillary endothelial cells with precise spatial control.

Keywords

biomedical electronics; electromagnetic actuators; microfluidics; micromanipulators; 2D magnetic manipulation; IC/microfluidic hybrid microsystem; bead-bound cells; biocompatible environment; bovine capillary endothelial cells; individual biological cell manipulation; microcoil array; patterned magnetic fields; spatial cell control; suspending magnetic-bead-tagged biological cells; Biological cells; Hospitals; Hybrid integrated circuits; Magnetic fields; Magnetic levitation; Medical diagnosis; Medical diagnostic imaging; Microfluidics; Pediatrics; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Circuits Conference, 2005. Digest of Technical Papers. ISSCC. 2005 IEEE International

Conference_Location

San Francisco, CA

ISSN

0193-6530

Print_ISBN

0-7803-8904-2

Type

conf

DOI

10.1109/ISSCC.2005.1493878

Filename

1493878