Title :
In vivo guided numerical modeling of pulmonary venous waveforms: a paradigm for applied physiology research
Author :
Firstenberg, Michael S. ; Garcia, Mario J. ; Smedira, Nicholas ; Greenberg, Neil L. ; Prior, David L. ; Scalia, Gregory M. ; Thomas, James D.
Author_Institution :
Cardiovascular Imaging Center, Cleveland Clinic Found., OH, USA
fDate :
6/21/1905 12:00:00 AM
Abstract :
The determination of pulmonary venous velocities from pulsed Doppler echocardiography is valuable for the assessment of left ventricular diastolic dysfunction, yet little is known regarding the relationship between actual pressure gradients and measured velocities. Combining results of in vivo experiments and numerical modeling, a linear relationship was observed between actual pulmonary venous-left atrial pressure gradients and measured velocities (convective forces) measured using pulsed Doppler echocardiography. Strong model correlations were observed for the systolic (y=0.20x-0.13, r=0.97) and diastolic (y=0.25x-0.34, r=0.99) phases of the pulmonary venous waveform. In vivo results were similar for the systolic (y=0.234x+0.01x, r=0.82) and diastolic (y=0.22x+0.09, r=0.81) phases. Modeling, combined with in vivo experiments can complement each other in understanding complex physiology
Keywords :
Doppler measurement; echocardiography; haemodynamics; lung; physiological models; applied physiology research paradigm; complex physiology understanding; diastolic phase; hemodynamic modeling; in vivo experiments; in vivo guided numerical modeling; model correlations; pulmonary venous waveforms; pulmonary venous-left atrial pressure gradients; pulsed Doppler echocardiography; strong model correlations; systolic phase; Echocardiography; Equations; Fluid flow measurement; Force measurement; In vivo; Numerical models; Physiology; Pressure measurement; Pulse measurements; Velocity measurement;
Conference_Titel :
Computers in Cardiology, 1999
Conference_Location :
Hannover
Print_ISBN :
0-7803-5614-4
DOI :
10.1109/CIC.1999.825894
