Title :
Single-hole microshell particles for loading temozolomide
Author :
Mair, L.O. ; Nacev, Alek ; Urdaneta, M.G. ; Stepanov, P.Y. ; Sarwar, Arslan ; Weinberg, I.N. ; Shapiro, Brian
Author_Institution :
Weinberg Med. Phys. LLC, Bethesda, MD, USA
Abstract :
We demonstrate magnetic metal-polymer composite microshell particles having a single nanoscale hole in the metal microshell layer. We load the surfaces of these particles with temozolomide (TMZ), a common brain cancer chemotherapeutic, and confirm loading via UV-vis spectroscopy.
Keywords :
biomedical materials; brain; cancer; drug delivery systems; drugs; magnetic materials; nanocomposites; nanomagnetics; nanomedicine; nanoparticles; polymer blends; ultraviolet spectra; visible spectra; brain cancer chemotherapeutic; magnetic metal-polymer composite microshell particles; temozolomide loading; ultraviolet-visible spectroscopy; Chemicals; Drugs; Loading; Magnetic resonance imaging; Methanol; Nanoparticles; Surface treatment; PLGA; nanoparticles; temozolomide;
Conference_Titel :
MEMS & NEMS (MAMNA), 2014 Spring Symposium: From Lab to Life: Field Based Applications of
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-4799-4678-5
DOI :
10.1109/MAMNA.2014.6845237
