Study on the fabrication and characterization of a novel n-HA/mulit-(animo acid) compolymer Composite

A novel nano-hydroxyapatite/multi-(amino acid) copolymer (n-HA/MACP) composite was prepared by in situ polymerization and characterized by FT-IR XRD, mechanical measurement, in vitro degradation experiments and cell growth behavior. FT-IR and XRD results showed that the composite was composed of n-HA and an amide linkage structure and hydrogen bond was formed between n-HA and the copolymer. The composite showed different compressive strength of 176-263 MPa, varying with the n-HA content in it. A 24-week incubation in phosphate buffered saline exhibited that the composite was degradable with the weight loss of 20.7 wt% and the degradation showed no significant effects on the pH of the soaking medium.