Heart rate variability analysis in clinical pharmacology by joint time-frequency methods

Author

Adelmann, H.G.

Author_Institution

Inst. for Clinical Pharmacology, BAYER AG, Wuppertal, Germany

fYear

1999

fDate

6/21/1905 12:00:00 AM

Firstpage

643

Lastpage

645

Abstract

We are applying heart rate variability (HRV) analysis in clinical pharmacology to investigate the autonomic nervous system´s (ANS) response to drug pharmacodynamics. Here, the HRV time series under investigation are usually nonstationary, thus not suitable for spectral analysis by Fourier- or autoregressive (AR) methods. We designed a PC based system with LabView^TM for HRV analysis including spectral analysis in the joint time-frequency (JTF) domain that is suitable for nonstationary data. We found a 2nd to 3rd order Gabor spectrogram useful for the analysis of HRV data. We would like to promote JTF analysis of heart rate variability in clinical pharmacology to gain insight into the complex ANS regulation and ANS response to drugs. There is however need for an extension of the current 1996 guidelines for HRV analysis to cover joint time-frequency methods in order to get standardization

Keywords

biocontrol; cardiology; medical diagnostic computing; medical signal processing; microcomputer applications; neurophysiology; patient treatment; spectral analysis; time series; time-frequency analysis; LabView; PC based system; autonomic nervous system´s response; clinical pharmacology; complex autonomic nervous system regulation; drug pharmacodynamic; heart rate variability analysis; heart rate variability time series; joint time-frequency domain; nonstationary data; second-third order Gabor spectrogram; spectral analysis; standardization; Autonomic nervous system; Data analysis; Design methodology; Drugs; Guidelines; Heart rate variability; Spectral analysis; Spectrogram; Standardization; Time frequency analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology, 1999

Conference_Location

Hannover

ISSN

0276-6547

Print_ISBN

0-7803-5614-4

Type

conf

DOI

10.1109/CIC.1999.826053

Filename

826053