• DocumentCode
    167321
  • Title

    Using associators to generate ensemble biclustering from multiple evolved biclusterings

  • Author

    Eun-Youn Kim ; Ashlock, Daniel

  • Author_Institution
    Korean Res. Inst. for Biosci. & Biotechnol., Daejeon, South Korea
  • fYear
    2014
  • fDate
    21-24 May 2014
  • Firstpage
    1
  • Lastpage
    8
  • Abstract
    Biclustering is a data mining technique that performs clustering of the rows and columns of a matrix simultaneously. An associator is a numerical measure of how closely associated two objects should be. Ensemble methods integrate information from multiple solutions to generate superior solutions. A simple evolutionary algorithm to quickly locate multiple biclusterings of synthetic test data. The good submatrices of these biclusterings are then used as associators. Associators are accumulated across many runs of the evolutionary algorithm to create a master association matrix. This matrix is then used, via simultaneous hierarchical clustering, to create a final ensemble biclustering. Results are presenting on tuning the evolutionary algorithm as well as for the overall biclustering algorithm. The algorithm correctly locates planted clusters in the data, providing proof of concept for the ensemble technique. The technique is modular with the evolutionary algorithm, fitness function, and ensemble integration technique all easily swapped for other techniques.
  • Keywords
    bioinformatics; data mining; evolutionary computation; numerical analysis; data mining; ensemble biclustering; ensemble integration technique; master association matrix; multiple evolved biclusterings; numerical analysis; simultaneous hierarchical clustering; Clustering algorithms; Data mining; Evolutionary computation; Robustness; Sociology; Standards; Statistics;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Computational Intelligence in Bioinformatics and Computational Biology, 2014 IEEE Conference on
  • Conference_Location
    Honolulu, HI
  • Type

    conf

  • DOI
    10.1109/CIBCB.2014.6845530
  • Filename
    6845530