Effect of surface topography of zirconia coating on its bioactivity and osteoblast response

12.8mol% calcia-zirconia coatings with nanostructured surface were prepared using plasma spraying technology. The bioactivity, cytocompatibility as well as their correlation with the surface topography and nanostructure of coatings were explored. Simulated body fluid (SBF) immersion test shows that the as-sprayed zirconia coating can induce apatite precipitation on its surface, whereas the heated and polished ones can not. It indicates the significant role of the nanostructured surface on the bioactivity of zirconia coating. In vitro MG63 cells culture experiments revealed that rough surface are beneficial for cell spreading and cellular skeleton reorganization. In addition, it was proved that nanostructure can enhance cell proliferation.