Title :
Two dimensional coaxial circular elements in finite element method to study calcium diffusion in cardiac myocytes
Author :
Pathak, K. ; Adlakha, Neeru
Abstract :
The calcium signaling plays an important role in expansion and contraction of Myocytes. This calcium signaling is achieved by diffusion of calcium and buffering mechanisms in cardiac myocytes. In this paper an attempt has been made to develop model calcium signaling in myocytes incorporating diffusion of calcium and excess buffers. The model has been developed for a two dimensional steady state case. Appropriate boundary conditions have been framed. The finite element method has been employed to obtain the solution. The numerical results have been used to study the effect of buffers on calcium distribution in Myocytes.
Keywords :
biodiffusion; calcium; cardiology; cellular biophysics; finite element analysis; boundary conditions; buffering mechanisms; calcium diffusion; calcium signaling; cardiac myocytes; finite element method; myocytes contraction; myocytes expansion; two-dimensional coaxial circular elements; two-dimensional steady state case; Approximation methods; Bismuth; Boundary conditions; Calcium; Equations; Finite element analysis; Mathematical model; cardiac myocytes; excess buffer; finite element method; reaction diffusion equation;
Conference_Titel :
Engineering (NUiCONE), 2013 Nirma University International Conference on
Conference_Location :
Ahmedabad
Print_ISBN :
978-1-4799-0726-7
DOI :
10.1109/NUiCONE.2013.6780200
