Moment closure for biochemical networks

Moment closure is a technique used to construct systems of differential equations to approximately compute means, standard deviations, and correlations between molecule counts of species involved in chemical reactions. These techniques are especially useful when the number of molecules exhibit large stochasticity, which is not uncommon in bio-chemical reactions. We discusses several approaches to moment closure that have been proposed in the literature and that have been recently implemented in a Matlab toolbox.