Title :
An 87mA·min iontophoresis controller IC with dual-mode impedance sensor for patch-type transdermal drug delivery system
Author :
Kiseok Song ; Unsoo Ha ; Jaehyuk Lee ; Kyeongryeol Bong ; Hoi-Jun Yoo
Author_Institution :
KAIST, Daejeon, South Korea
Abstract :
In this paper, we present an iontophoresis controller IC with real-time monitoring of total injected charge quantity and skin condition. The proposed IC contains 32-level programmable current stimulator, a temperature sensor and a dual impedance sensor to monitor skin temperature, contact and tissue impedances. The measured temperature and impedances, related with the skin condition, are used for adaptive charge injection by modifying the current stimulation levels through the real-time feedback path. An implemented fabric patch type drug delivery system provides up to 87mA-min dosage larger than the dosage range (80mA-min) of commercial iontophoresis patches [4].
Keywords :
CMOS integrated circuits; biological tissues; biomedical electronics; biomedical measurement; drug delivery systems; skin; temperature measurement; temperature sensors; 1P6M CMOS process; adaptive charge injection; contact; dual-mode impedance sensor; iontophoresis controller IC; patch-type transdermal drug delivery system; programmable current stimulator; real-time feedback path; skin condition; skin temperature monitoring; temperature sensor; tissue impedances; Current measurement; Drug delivery; Impedance; Impedance measurement; Skin; Temperature measurement; Temperature sensors;
Conference_Titel :
Solid-State Circuits Conference Digest of Technical Papers (ISSCC), 2013 IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
978-1-4673-4515-6
DOI :
10.1109/ISSCC.2013.6487653
