Blood flow simulation in a stenotic vessel surrounded by biological tissue

An abnormal narrowing of a blood vessel (stenosis) is investigated in this study. The present work provides a simulation of blood in a vessel with 50% stenosis. In addition, the effects of tissue surrounding the blood vessel on displacements and stresses in stenotic vessel wall are considered. The analysis consists of two distinct but coupled procedures: first, a fluid-dynamics analysis including a calculation of the velocity field and pressure distribution in the blood (variable in time and in space); second, a mechanical analysis of the deformation of the tissue and vessel. To do so, COMSOL Multiphysics as a powerful software was used to simulate the wall-blood interaction. The diameter of vessel is 8 millimeters and the blood assumed to be a Newtonian and incompressible fluid. In addition to, the walls of vessel and surrounding biological tissue were assumed to be a hyper-elastic material. The results indicated that the stresses and displacement of blood vessel are completely affected by surrounding tissue. In the other hand for studying blood flow in the vessel we cannot ignore the effects of surrounding tissue and flexibility of the vessel walls. Furthermore velocity and shear rate of blood flow were also investigated.