A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

Epilepsy is one of the most common neurological disorders. Around 1% of the world´s population is affected, and nearly 25% of the patients cannot be treated by available therapies. Recently, seizure-triggered feedback electrical stimulation has been proved to effectively suppress pathological brain activities [1], but devices with accurate detection and effective stimulation for real-time seizure control are still unavailable. In this paper, a fully integrated 8-channel closed-loop seizure-control SoC with entropy-and-spectrum-aided seizure detection and adaptive neural stimulation is presented. This chip is powered wirelessly, aiming for implantable devices. The functionality of the fabricated chip is verified in animal tests.