Title :
Peptide surface modification of PLA ultrasound contrast agent for targeting
Author :
Leodore, L.M. ; Lathia, Justin D. ; Wheatley, Margaret A.
Author_Institution :
Dept. of Bioscience & Biotechnol., Drexel Univ., Philadelphia, PA, USA
Abstract :
REDV and RGD peptide sequences were conjugated to hollow microspheres to develop targeted PLA ultrasound contrast agents that enhance imaging. The microspheres were coated with either RGD or REDV peptide sequences that target integrins active in angiogensis, αvβ3 and αvβ5. The microspheres were then shown to bind to human breast carcinoma cells in vitro within 5 minutes. The peptide modified microspheres makes them ideal candidates for targeted imaging.
Keywords :
biomedical ultrasonics; cancer; cellular biophysics; mammography; organic compounds; tumours; 5 min; PLA ultrasound contrast agent; REDV peptide sequences; RGD peptide sequences; angiogenesis; hollow microspheres; human breast cancer; human breast carcinoma cell binding; human breast carcinoma cells; imaging enhancement; integrins; peptide modified microspheres; peptide sequences; peptide surface modification; targeted PLA ultrasound contrast agents; targeted imaging; targeting; tumor growth; Adhesives; Biological materials; Breast; Cells (biology); Humans; Peptides; Programmable logic arrays; Proteins; Sequences; Ultrasonic imaging;
Conference_Titel :
Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of
Print_ISBN :
0-7803-7767-2
DOI :
10.1109/NEBC.2003.1216059
