Model investigation of the changes in mechanical properties of a blood vessel with a blood flow obstruction

Author

Kuhn, Irene ; Drzewiecki, Gary

Author_Institution

Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA

fYear

2003

Firstpage

219

Lastpage

220

Abstract

We have made latex tube models of blood vessels, either with or without simulated atherosclerotic disease, in order to study changes in their mechanical properties. We have measured volume and pressure for the models of normal and obstructed vessels, then plotted and compared their compliance curves. We found that the compliance of the model of a diseased vessel did differ from that of the model of a normal vessel. The maximum compliance of the modeled diseased vessel shifted to a lower pressure relative to that of the modeled clear vessel. This finding implies that detection of compliance differences might be used as a method to diagnose atherosclerotic disease noninvasively.

Keywords

biomechanics; blood vessels; diseases; haemodynamics; patient diagnosis; physiological models; blood flow obstruction; blood vessel; compliance curves; diseased vessel; latex tube models; mechanical properties changes; noninvasive diagnosis; normal vessel; obstructed vessels; pressure; simulated atherosclerotic disease; volume; Arteries; Atherosclerosis; Biomedical engineering; Biomedical measurements; Blood flow; Blood vessels; Diseases; Mechanical factors; Pressure measurement; Volume measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of

Print_ISBN

0-7803-7767-2

Type

conf

DOI

10.1109/NEBC.2003.1216072

Filename

1216072