Title :
Combined effect of mercuric ion and silver ion on the clotting time of blood
Author :
Phatak, Uma R. ; Kristol, David ; Arora, Rohit R. ; Spillert, Charles R.
Author_Institution :
New Jersey Inst. of Technol., Newark, NJ, USA
Abstract :
The mercuric ion (Hg2+) has been shown to have a procoagulant effect on citrated whole blood through its excitation of the extrinsic pathway. The silver ion (Ag+) affects the intrinsic pathway of blood coagulation also producing a shortened clotting time. This in vitro study involved mixing citrated whole blood (CWB) with mercuric nitrate Hg(NO3)2, silver nitrate AgNO3, and the combination of the two. The eight samples were incubated for ten minutes at 37°C and were analyzed by an Amelung KC 4A clot detector. The results show that the combination of Ag+ and Hg2+ significantly reduces the clotting time (p<.002).
Keywords :
biochemistry; coagulation; haemorheology; mercury (metal); silver; 10 min; 37 C; Ag; Amelung KC 4A clot detector; Hg; Hg(NO3)2; citrated whole blood; clotting time reduction; extrinsic pathway excitation; in vitro study; mercuric ion; procoagulant effect; silver ion; Analysis of variance; Biomembranes; Blood; Coagulation; Detectors; Hospitals; In vitro; Mercury (metals); Production; Silver;
Conference_Titel :
Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of
Print_ISBN :
0-7803-7767-2
DOI :
10.1109/NEBC.2003.1216091
