Title :
Effect of polymer composition on in vivo ultrasound contrast agent performance
Author :
Lathia, Justin D. ; Le, Ngocyen T. ; El-Sherif, Dalia ; Forsberg, Fleming ; Jin-Bin Liu ; Merton, D.A. ; Shimiz, M. ; Goldberg, B.B. ; Wheatley, M.A.
Author_Institution :
Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA
Abstract :
Polymer composition, the ratio of lactic acid (LA) to glycolic acid (GA), was evaluated for its contribution to the acoustic enhancement of a poly (co-lactic-glycolic) acid (PLGA) ultrasound contrast agent. Contrast agents were prepared from four different polymer compositions (LA:GA): 100:0, 85:15, 75:25, 50:50 and tested in vivo. The results indicate that all contrast agents perform well in vivo but the 50:50, which had the shortest usable life-time. The performance of the contrast agents was dependent on the ratio of LA to GA and should be considered in the design of polymeric contrast agents.
Keywords :
biomedical materials; biomedical ultrasonics; image enhancement; medical image processing; polymers; acoustic enhancement; in vivo ultrasound contrast agent performance; lactic acid; medical diagnostic imaging; poly co-lactic-glycolic acid; polymer composition; usable life-time; Acoustic testing; Biomedical acoustics; Biomedical engineering; Chemical engineering; Degradation; In vivo; Polymers; Rabbits; System testing; Ultrasonic imaging;
Conference_Titel :
Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of
Print_ISBN :
0-7803-7767-2
DOI :
10.1109/NEBC.2003.1216126
