DocumentCode :
1720953
Title :
Simulation of microimages emitted by virtual array of testing oligonucleotides
Author :
Cysewska-Sobusiak, Anna ; Boltrukiewicz, Michal
Author_Institution :
Inst. of Electron. & Telecommun., Tech. Univ. Poznan, Poland
fYear :
2002
fDate :
6/24/1905 12:00:00 AM
Firstpage :
100
Lastpage :
104
Abstract :
This paper is concerned with utilization of virtual reality in biomeasurements. Presented questions have focused on predicting changes in the virtual optical response as a result of simulated changes in a considered DNA sequence composition. Relationships between thermodynamic and optical properties of a given sequence are taken in considering a light-directed library of testing oligonucleotides. The oligonucleotides embedded in the library volume make the array of short known sequences that are assumed as the testers. Simulated microimages entitled by a virtual array correspond to the sites where hybridization process is performed as a result of the DNA sequence base pairing characteristics. Presented simulation refers to changes in fluorescence signals to be sensed from the lighting array made by pixels, which intensities depend on parameters of the objects located in particular array sites.
Keywords :
DNA; biological techniques; biology computing; fluorescence; molecular biophysics; optical arrays; virtual reality; DNA sequence composition; fluorescence signals changes; microimages simulation; oligonucleotides testing; optical properties; short known sequences array; simulated changes; thermodynamic properties; virtual array; virtual optical response; Biomedical optical imaging; DNA; Libraries; Optical arrays; Optical sensors; Predictive models; Sequences; Stimulated emission; Testing; Virtual reality;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Virtual and Intelligent Measurement Systems, 2002. VIMS '02. 2002 IEEE International Symposium on
Print_ISBN :
0-7803-7344-8
Type :
conf
DOI :
10.1109/VIMS.2002.1009365
Filename :
1009365
Link To Document :
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