DocumentCode :
1726092
Title :
Parylene neuro-cages for live neural networks study
Author :
Qing He ; Meng, E. ; Yu-Chong Tai ; Rutherglen, C.M. ; Erickson, J. ; Pine, J.
Author_Institution :
Dept. of Electr. Eng., California Inst. of Technol., Pasadena, CA, USA
Volume :
2
fYear :
2003
Firstpage :
995
Abstract :
Here we present a surface-micromachined Parylene neuro-cage array for the in vitro study of live neural networks. Various types of neuro-cages have been fabricated and several adhesion promotion techniques have been explored. The biocompatibility and mechanical robustness of Parylene neuro-cages have been demonstrated through cell culture experiments. Dissociated neuronal cell bodies have been inserted one to a cage and cultured, allowing neurites to grow out through Parylene channels and form live neural networks. In addition, there is no observable difference between neural growth on Parylene and on oxide surfaces. It is possible to use the same or slightly modified cage structures to accommodate different cells, leading to possible applications of this technology in cell study and drug discovery.
Keywords :
adhesion; cellular biophysics; cellular neural nets; micromachining; neurophysiology; adhesion; biocompatibility; cell culture experiments; drug discovery; live neural networks; mechanical robustness; neuronal cell bodies; oxide surfaces; parylene channels; parylene neurocages; surface-micromachining; Adhesives; Biological neural networks; Cells (biology); Electrodes; Helium; In vitro; Neural networks; Neurons; Physics; Robustness;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
TRANSDUCERS, Solid-State Sensors, Actuators and Microsystems, 12th International Conference on, 2003
Conference_Location :
Boston, MA, USA
Print_ISBN :
0-7803-7731-1
Type :
conf
DOI :
10.1109/SENSOR.2003.1216935
Filename :
1216935
Link To Document :
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