Title :
Remote switching of cellular activity using light through quantum dots
Author :
Lugo, Katherine ; Miao, Xiaoyu ; Rieke, Fred ; Lin, Lih Y.
Author_Institution :
Dept. of Electr. Eng., Univ. of Washington, Seattle, WA, USA
Abstract :
We report integration of CdTe quantum dot (QD) film with LnCap (prostate cancer) cell and CdSe QD probes with cortical neurons for control of cellular activity. We demonstrate the remote switching of cellular activity by exciting QDs with light. Changes in membrane potential and ionic currents are recorded using the patch-clamp method. Upon excitation, the cell shows activation of ion channels and hyperpolarization of the cell membrane.
Keywords :
II-VI semiconductors; cadmium compounds; cancer; cellular biophysics; membranes; optical switches; semiconductor quantum dots; wide band gap semiconductors; CdSe; CdTe; cell membrane; cellular activity; cortical neurons; hyperpolarization; ionic currents; light quantum dots; membrane potential; patch-clamp method; prostate cancer cell; remote switching; Biomembranes; Electric potential; Films; Ions; Neurons; Probes; Quantum dots;
Conference_Titel :
Optical MEMS and Nanophotonics (OPT MEMS), 2010 International Conference on
Conference_Location :
Sapporo
Print_ISBN :
978-1-4244-8926-8
Electronic_ISBN :
978-1-4244-8925-1
DOI :
10.1109/OMEMS.2010.5672180
