Technology and design of innovative flexible electrode for biomedical applications

Author

Balucani, Marco ; Nenzi, P. ; Crescenzi, Rocco ; Marracino, P. ; Apollonio, Francesca ; Liberti, Micaela ; Densi, A. ; Colizzi, C.

Author_Institution

DIET, Sapienza Univ. di Roma, Rome, Italy

fYear

2011

Firstpage

1319

Lastpage

1324

Abstract

The electrochemotherapy is an effective treatment that requires the application of an intense electric field to the tumoral tissue to open the cellular membrane and deliver drugs. This work will present the results of the ongoing research project, showing a new technology and design geometry that allows to realize flexible electrodes able to wrap biological tissues bringing the necessary electric field intensity for the electroporation of cells to reach a unique penetration depth to the centimeter range. The flexible electrode is realized by conversion of porous silicon into nano-porous metals (copper and/or gold) filled by a biocompatible thermoplastic polymer.

Keywords

biomedical electrodes; drug delivery systems; flexible structures; biocompatible thermoplastic polymer; biological tissue; biomedical application; cell electroporation; cellular membrane; design geometry; drug delivery; electric field intensity; electrochemotherapy; innovative flexible electrode; nanoporous metal; porous silicon; tumoral tissue; Adhesives; Conductivity; Copper; Electric fields; Electrodes; Gold; Polymers;

fLanguage

English

Publisher

ieee

Conference_Titel

Electronic Components and Technology Conference (ECTC), 2011 IEEE 61st

Conference_Location

Lake Buena Vista, FL

ISSN

0569-5503

Print_ISBN

978-1-61284-497-8

Electronic_ISBN

0569-5503

Type

conf

DOI

10.1109/ECTC.2011.5898682

Filename

5898682