Title :
Preliminary results from a novel CCD-based imaging system for biomedical applications
Author :
MacDonald, J.H. ; Wells, K. ; Ott, R.J.
Author_Institution :
Dept. of Phys., R. Marsden Hospital, Sutton, UK
Abstract :
A digital autoradiography system, incorporating a cooled scientific charge coupled device (CCD) is in development at the Physics Department of the Institute of Cancer Research (ICR). The ICR system is designed to image β-particles and low energy X-rays from radiolabelled biological tissue samples, utilising direct irradiation of the CCD. This prototype system displays position resolution of 30 μm over an area of ~4 cm2. System response is linear over a dynamic range of at least 104, with signal to noise ratio approaching 300. The different components of system noise are discussed,along with the optimisation of integration times to minimise their effect. The potential application of the system to “multimodality” imaging-the automatic registration of optical and radionuclide images of a stained tissue sample-is discussed
Keywords :
CCD image sensors; biological techniques; radioisotope imaging; β-particles; CCD-based imaging system; Institute of Cancer Research; automatic registration; biomedical applications; cooled scientific charge coupled device; digital autoradiography system; direct irradiation; low energy X-rays; multimodality imaging; optical images; position resolution; prototype system; radiolabelled biological tissue samples; radionuclide images; stained tissue sample; system noise components; system response; Biological tissues; Cancer; Charge coupled devices; Charge-coupled image sensors; Displays; Optical imaging; Optical noise; Physics; Prototypes; X-rays;
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference Record, 1995., 1995 IEEE
Conference_Location :
San Francisco, CA
Print_ISBN :
0-7803-3180-X
DOI :
10.1109/NSSMIC.1995.501922
