• DocumentCode
    1737872
  • Title

    Simulation of thrombin generation during plasmatic coagulation and primary hemostasis

  • Author

    Ballet, Pascal ; Abgrall, Jean-François ; Rodin, Vincent ; Tisseau, Jacques

  • Author_Institution
    French Nat. Sch. of Eng., Brest, France
  • Volume
    1
  • fYear
    2000
  • fDate
    2000
  • Firstpage
    131
  • Abstract
    Describes a simulation of the platelet agglutination in a damaged vein. This agglutination, called plasmatic coagulation, appears in the human body and its malfunction involves dramatic diseases like thrombosis or hemophilia. We designed an in-machina experimentation that is very difficult to do in-vitro. The first aim of this simulation is to verify one of the biological models of plasmatic coagulation and primary hemostasis. The second aim is to test different ways to regulate the thrombin production. Then, we simulate a haemophilia-like disease and one of its possible treatments
  • Keywords
    blood; coagulation; digital simulation; diseases; medical computing; patient treatment; biological models; blood clotting; damaged vein; disease treatment; haemophilia; in-machina experimentation; malfunction; plasmatic coagulation; platelet agglutination; primary haemostasis; thrombin generation simulation; thrombin production regulation; thrombosis; Biological system modeling; Cells (biology); Coagulation; Computational modeling; Diseases; Immune system; In vitro; Laboratories; Plasma simulation; Proteins;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Systems, Man, and Cybernetics, 2000 IEEE International Conference on
  • Conference_Location
    Nashville, TN
  • ISSN
    1062-922X
  • Print_ISBN
    0-7803-6583-6
  • Type

    conf

  • DOI
    10.1109/ICSMC.2000.884977
  • Filename
    884977