DocumentCode
1737872
Title
Simulation of thrombin generation during plasmatic coagulation and primary hemostasis
Author
Ballet, Pascal ; Abgrall, Jean-François ; Rodin, Vincent ; Tisseau, Jacques
Author_Institution
French Nat. Sch. of Eng., Brest, France
Volume
1
fYear
2000
fDate
2000
Firstpage
131
Abstract
Describes a simulation of the platelet agglutination in a damaged vein. This agglutination, called plasmatic coagulation, appears in the human body and its malfunction involves dramatic diseases like thrombosis or hemophilia. We designed an in-machina experimentation that is very difficult to do in-vitro. The first aim of this simulation is to verify one of the biological models of plasmatic coagulation and primary hemostasis. The second aim is to test different ways to regulate the thrombin production. Then, we simulate a haemophilia-like disease and one of its possible treatments
Keywords
blood; coagulation; digital simulation; diseases; medical computing; patient treatment; biological models; blood clotting; damaged vein; disease treatment; haemophilia; in-machina experimentation; malfunction; plasmatic coagulation; platelet agglutination; primary haemostasis; thrombin generation simulation; thrombin production regulation; thrombosis; Biological system modeling; Cells (biology); Coagulation; Computational modeling; Diseases; Immune system; In vitro; Laboratories; Plasma simulation; Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
Systems, Man, and Cybernetics, 2000 IEEE International Conference on
Conference_Location
Nashville, TN
ISSN
1062-922X
Print_ISBN
0-7803-6583-6
Type
conf
DOI
10.1109/ICSMC.2000.884977
Filename
884977
Link To Document