Title :
Modeling linear-quadratic CFU survival parameters for daily fractionated radiation
Author :
Zimmer, John ; Blazek, Ed R. ; Chu, James ; Saxena, V. Amod
Author_Institution :
Dept. of Med. Phys., Rush Presbyterian St. Lukes Med. Center, Chicago, IL, USA
Abstract :
Daily fractionated and graded dose assays simulate the dose and timing of standard external beam treatments. These assays measure the survival of a colony forming units (CFU) rather than cell survival per se. A spreadsheet is used to model these daily treatment assays in terms of (1) cell killing from individual exposures and (2) repopulation doubling times
Keywords :
cellular effects of radiation; digital simulation; dosimetry; medical computing; physiological models; radiation therapy; spreadsheet programs; cell killing; cellular radiobiology; colony forming units; daily treatment assays; individual exposures; linear-quadratic CFU survival parameters modeling; repopulation doubling times; standard external beam treatments; treatment dose; treatments timing; tumor cells radiosensitivity; Equations; Fractionation; In vitro; Mathematical model; Measurement units; Medical treatment; Predictive models; Timing; Tumors;
Conference_Titel :
Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-6465-1
DOI :
10.1109/IEMBS.2000.897858
