In situ optical biopsy with a confocal microendoscope

Author

Gmitro, Arthur F. ; Rouse, Andrew R. ; Sabharwal, Y.S.

Author_Institution

Dept. of Radiol., Arizona Univ., Tucson, AZ, USA

Volume

2

fYear

2000

fDate

2000

Firstpage

1040

Abstract

A confocal microendoscope for in situ optical biopsy has been developed. The system couples a slit-scan confocal fluorescence microscope to an optical catheter, consisting of a coherent fiber-optic imaging bundle, or a fiber bundle with a miniature objective and hydraulic focusing mechanism. The confocal microendoscope provides adequate image quality to visualize individual cells and subcellular structures. Vital fluorescent dyes are used with the system as selective stains for histopathologic evaluation of disease

Keywords

bio-optics; biological tissues; biomedical imaging; cellular biophysics; fluorescence; optical fibres; optical images; optical microscopy; CCD camera; GRIN lens; coherent fiber-optic imaging bundle; confocal microendoscope; disease; fluorescent dyes; histopathologic evaluation; hydraulic focusing mechanism; in situ optical biopsy; individual cells visualisation; living tissues; miniature objective; optical catheter; selective stains; slit-scan confocal fluorescence microscope; subcellular structures; Biomedical optical imaging; Biopsy; Catheters; Fluorescence; Focusing; Image quality; Optical coupling; Optical imaging; Optical microscopy; Visualization;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1094-687X

Print_ISBN

0-7803-6465-1

Type

conf

DOI

10.1109/IEMBS.2000.897904

Filename

897904