Title :
Surfactant/antioxidant/ATP therapy after high-dose irradiation of isolated skeletal muscle cells
Author :
Hannig, Jurgen ; Greenebaum, B. ; Carrillo, Cinthya S. ; Lee, Raphael C.
Author_Institution :
Dept. of Surg., Chicago Univ., IL, USA
Abstract :
Ionizing radiation is known to produce lipid peroxidation in cell membranes besides DNA damage. At high irradiation levels this results in a loss of cell membrane integrity followed by acute cell necrosis in the time course of hours. The authors´ investigation shows that the membrane sealing surfactant Poloxamer 188 in combination with antioxidants and ATP is effective in improving postirradiation survival
Keywords :
DNA; biological effects of gamma-rays; cellular effects of radiation; muscle; patient treatment; surfactants; DNA damage; acute cell necrosis; cell membranes; cell survival; cellular radiobiology; high-dose irradiation; isolated skeletal muscle cells; membrane sealing; membrane sealing surfactant Poloxamer 188; postirradiation survival improvement; surfactant/antioxidant/ATP therapy; Biomembranes; Cells (biology); DNA; Ionizing radiation; Lipidomics; Medical treatment; Muscles; Polymers; Scanning electron microscopy; Testing;
Conference_Titel :
Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-6465-1
DOI :
10.1109/IEMBS.2000.900540
