Title :
Hemodynamics of atherosclerotic mice
Author :
Hartley, Craig J. ; Reddy, Anillcumar K. ; Madala, Sridhar ; Martin-McNulty, Baby ; Vergona, Ronald ; Sullivan, Mark E. ; Halks-Miller, Meredith ; Taffet, George E. ; Michael, Lloyd H. ; Entman, Mark L. ; Wang, Yi-Xin
Author_Institution :
Dept. of Med., Baylor Coll. of Med., Houston, TX, USA
Abstract :
Apolipoprotein-E knockout mice are often used as models of human atherosclerosis, but little is known of the hemodynamic consequences. Using noninvasive Doppler methods, it was found that heart rate and blood pressure were normal but that aortic pulse wave velocity, mean aortic and mitral blood velocities, and peripheral wave reflections were increased. It was also demonstrated that heart weight/body weight ratio was increased, and that hematocrit was decreased. The changes are consistent with decreased peripheral vascular resistance and compliance and with volume overload cardiac hypertrophy
Keywords :
Doppler measurement; biomedical ultrasonics; blood flow measurement; blood pressure measurement; blood vessels; cardiovascular system; aortic pulse wave velocity; apolipoprotein-E knockout mice; atherosclerotic mice; blood pressure; cardiovascular system; haemodynamics; heart rate; heart weight/body weight ratio; hematocrit; mean aortic blood velocity; mitral blood velocity; noninvasive Doppler methods; peripheral vascular compliance; peripheral vascular resistance; peripheral wave reflections; volume overload cardiac hypertrophy; Atherosclerosis; Carotid arteries; Heart; Hemodynamics; Humans; Lesions; Mice; Probes; Pulse measurements; Sternum;
Conference_Titel :
Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-6465-1
DOI :
10.1109/IEMBS.2000.900578
