Effects of Rare Earth Nano Material on the Immune Function of Cavies

The influences of rare earth nano materials on the immune function of cavies have been investigated to verify its biological safety. The experiments were conducted by four ways of staining toxicant including skin-contacting, oral-feeding, vein-injecting as well as muscle-injecting and four resultant groups was classified for the analysis of individual effects. The cavies in first group (skin-contacting) were depilated in the back and then daubed rare earth nano material in 100 mg/cm²once a day for 30 days. The cavies in second group (oral-feeding) were fed 300 mgs of nano rare earth solution with the concentration of 50 % 4 times every other day (7 days). The other two groups of cavies, vein-injecting and muscle-injecting ones, were both injected 0.15 mLs of 10 % rare earth nano solution times every other day (7 days). Each group of cavies was killed in two batches separately on the 30th day and 90th day after staining toxicant, followed by the experiments of molecular and cellular immunity, and then the pathological sections were observed. For those cavies treated at 30 days, the immune function pronouncedly dropped and for the other group, their immune function didn’t recover to the normal level even after 90 days. Nano RE materials used in this paper caused the abnormality of the immune function and made it turbulent, which showed that these materials broke the immune function of the organism.