Title :
Micro- and Nanotechnology for HIV/AIDS Diagnostics in Resource-Limited Settings
Author :
Damhorst, Gregory L. ; Watkins, N.N. ; Bashir, Rumaan
Author_Institution :
Dept. of Bioeng. & the Micro & Nanotechnol. Lab., Univ. of Illinois at Urbana-Champaign, Urbana, IL, USA
Abstract :
Thirty-four million people are living with HIV worldwide, a disproportionate number of whom live in resource-limited settings. Proper clinical management of AIDS, the disease caused by HIV, requires regular monitoring of both the status of the host´s immune system and levels of the virus in their blood. Therefore, more accessible technologies capable of performing a CD4+ T cell count and HIV viral load measurement in settings where HIV is most prevalent are desperately needed to enable better treatment strategies and ultimately quell the spread of the virus within populations. This review discusses micro- and nanotechnology solutions to performing these key clinical measurements in resource-limited settings.
Keywords :
biomedical measurement; blood; cellular biophysics; diseases; microorganisms; nanomedicine; patient diagnosis; patient monitoring; reviews; AIDS diagnostics; CD4+ T cell count; HIV diagnostics; HIV viral load measurement; blood; clinical management; clinical measurements; disease; host immune system; microtechnology solutions; nanotechnology solutions; regular monitoring; resource limited settings; treatment strategies; virus levels; Blood; DNA; Human immunodeficiency virus; Immune system; Plasmas; Proteins; RNA; Global health; human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS); micro- and nanotechnology; point-of-care (PoC) diagnostics; Biomedical Engineering; CD4 Lymphocyte Count; Developing Countries; HIV Infections; Humans; Microtechnology; Nanomedicine; Point-of-Care Systems; Viral Load; World Health;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2013.2244894