Title :
Miniaturized Passive Hydrogel Check Valve for Hydrocephalus Treatment
Author :
Schwerdt, Helen N. ; Bristol, Ruth E. ; Junseok Chae
Author_Institution :
Dept. of Electr. Eng., Arizona State Univ., Tempe, AZ, USA
Abstract :
Improvements in cerebrospinal fluid (CSF) draining techniques for treatment of hydrocephalus are urgently sought after to substitute for current CSF shunts that are plagued by high failure rates. The passive check valve aims to restore near natural CSF draining operations while mitigating possible failure mechanisms caused by finite leakage or low resilience that frequently constrain practical implementation of miniaturized valves. A simple hydrogel diaphragm structures core passive valve operations and enforce valve sealing properties to substantially lower reverse flow leakage. Experimental measurements demonstrate realization of targeted cracking pressures (PT ≈ 20-110 mmH2O) and operation at -800 <; ΔP <; 600 mmH2O without observable degradation or leakage.
Keywords :
biomechanics; brain; cracks; diaphragms; fracture; hydrogels; medical disorders; neurophysiology; patient treatment; cerebrospinal fluid draining techniques; core passive valve operations; current CSF shunts; enforce valve sealing properties; failure mechanisms; high failure rates; hydrocephalus treatment; low reverse flow leakage; miniaturized passive hydrogel check valve; miniaturized valves; natural CSF draining operations; simple hydrogel diaphragm structures; targeted cracking pressure realization; Biomembranes; Fluids; Iterative closest point algorithm; Silicon; Substrates; Valves; Check valve; hydrogel; implantable microsystem; intracranial pressure (ICP) regulation; passive valve;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2013.2290291