DocumentCode :
1758394
Title :
Representing Variability and Transmural Differences in a Model of Human Heart Failure
Author :
Elshrif, Mohamed M. ; Pengcheng Shi ; Cherry, Elizabeth M.
Author_Institution :
B. Thomas Golisano Coll. of Comput. & Inf. Sci., Rochester Inst. of Technol., Rochester, NY, USA
Volume :
19
Issue :
4
fYear :
2015
fDate :
42186
Firstpage :
1308
Lastpage :
1320
Abstract :
During heart failure (HF) at the cellular level, the electrophysiological properties of single myocytes get remodeled, which can trigger the occurrence of ventricular arrhythmias that could be manifested in many forms such as early afterdepolarizations (EADs) and alternans (ALTs). In this paper, based on experimentally observed human HF data, specific ionic and exchanger current strengths are modified from a recently developed human ventricular cell model: the O´Hara-Virág-Varró-Rudy (OVVR) model. A new transmural HF-OVVR model is developed that incorporates HF changes and variability of the observed remodeling. This new heterogeneous HF-OVVR model is able to replicate many of the failing action potential (AP) properties and the dynamics of both [Ca2+]i and [Na+]i in accordance with experimental data. Moreover, it is able to generate EADs for different cell types and exhibits ALTs at modest pacing rate for transmural cell types. We have assessed the HF-OVVR model through the examination of the AP duration and the major ionic currents´ rate dependence in single myocytes. The evaluation of the model comes from utilizing the steady-state (S-S) and S1-S2 restitution curves and from probing the accommodation of the HF-OVVR model to an abrupt change in cycle length. In addition, we have investigated the effect of chosen currents on the AP properties, such as blocking the slow sodium current to shorten the AP duration and suppress the EADs, and have found good agreement with experimental observations. This study should help elucidate arrhythmogenic mechanisms at the cellular level and predict unseen properties under HF conditions. In addition, this AP cell model might be useful for modeling and simulating HF at the tissue and organ levels.
Keywords :
bioelectric potentials; biological tissues; biomembrane transport; calcium; cardiology; diseases; muscle; sodium; ALT; Ca; EAD; HF changes; Na; O´Hara-Virág-Varró-Rudy model; S1-S2 restitution curves; alternans; arrhythmogenic mechanisms; cellular level; early afterdepolarizations; electrophysiological properties; exchanger current strength; failing action potential properties; human heart failure; human ventricular cell model; ionic current strength; organ levels; single myocytes; slow sodium current blocking; steady-state restitution curves; tissue levels; transmural HF-OVVR model; transmural differences; variability; ventricular arrhythmias; Calcium; Data models; Hafnium; Heart; Indium tin oxide; Mathematical model; Protocols; Alternans; Alternans (ALTs); Early Afterdepolarizations; Heart Failure; O???Hara???Vir??g???Varr?????Rudy (OVVR); OVVR; Remodeling Ionic Currents; early afterdepolarizations (EADs); heart failure (HF); remodeling ionic currents;
fLanguage :
English
Journal_Title :
Biomedical and Health Informatics, IEEE Journal of
Publisher :
ieee
ISSN :
2168-2194
Type :
jour
DOI :
10.1109/JBHI.2015.2442833
Filename :
7120074
Link To Document :
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