A 10 kPixel CMOS Hall Sensor Array With Baseline Suppression and Parallel Readout for Immunoassays

Author

Gambini, Simone ; Skucha, K. ; Liu, P.P. ; Jungkyu Kim ; Krigel, R.

Author_Institution

Univ. of California, Berkeley, Berkeley, CA, USA

Volume

48

Issue

1

fYear

2013

fDate

Jan. 2013

Firstpage

302

Lastpage

317

Abstract

A CMOS microsystem for detecting microparticles in magnetic immunoassays uses the intrinsic dynamics of magnetization in super-paramagnetic materials to reduce measurement baseline by >;300× compared to conventional methods, and to achieve a signal to baseline ratio>; 1, with an improvement of over 50 × compared to systems that ignore bead dynamics. The microsystem integrates a 64 × 160 Hall-sensor array with column-parallel readout electronics that combine auto-zeroing and nested chopping to enable low-offset, power efficient signal acquisition and has an Allan deviation floor of 9 nT.

Keywords

CMOS integrated circuits; Hall effect transducers; biomedical electronics; patient diagnosis; readout electronics; sensor arrays; superparamagnetism; CMOS Hall sensor array; CMOS microsystem; baseline suppression; magnetic immunoassay; magnetization dynamics; microparticle detection; parallel readout; superparamagnetic materials; Arrays; Atmospheric measurements; Frequency measurement; Magnetic domains; Magnetization; Noise; Temperature measurement; Auto-zeroing; CMOS; Hall effect; chopping; immunosensor; magnetic immunoassays; offset; paramagnetism;

fLanguage

English

Journal_Title

Solid-State Circuits, IEEE Journal of

Publisher

ieee

ISSN

0018-9200

Type

jour

DOI

10.1109/JSSC.2012.2224531

Filename

6381487