Title :
A 10 kPixel CMOS Hall Sensor Array With Baseline Suppression and Parallel Readout for Immunoassays
Author :
Gambini, Simone ; Skucha, K. ; Liu, P.P. ; Jungkyu Kim ; Krigel, R.
Author_Institution :
Univ. of California, Berkeley, Berkeley, CA, USA
Abstract :
A CMOS microsystem for detecting microparticles in magnetic immunoassays uses the intrinsic dynamics of magnetization in super-paramagnetic materials to reduce measurement baseline by >;300× compared to conventional methods, and to achieve a signal to baseline ratio>; 1, with an improvement of over 50 × compared to systems that ignore bead dynamics. The microsystem integrates a 64 × 160 Hall-sensor array with column-parallel readout electronics that combine auto-zeroing and nested chopping to enable low-offset, power efficient signal acquisition and has an Allan deviation floor of 9 nT.
Keywords :
CMOS integrated circuits; Hall effect transducers; biomedical electronics; patient diagnosis; readout electronics; sensor arrays; superparamagnetism; CMOS Hall sensor array; CMOS microsystem; baseline suppression; magnetic immunoassay; magnetization dynamics; microparticle detection; parallel readout; superparamagnetic materials; Arrays; Atmospheric measurements; Frequency measurement; Magnetic domains; Magnetization; Noise; Temperature measurement; Auto-zeroing; CMOS; Hall effect; chopping; immunosensor; magnetic immunoassays; offset; paramagnetism;
Journal_Title :
Solid-State Circuits, IEEE Journal of
DOI :
10.1109/JSSC.2012.2224531
