DocumentCode :
1766206
Title :
Dextran-Coated GoldMag Nanoparticles Enhance the Colloidal Stability and Controlled-Release of Doxorubicin
Author :
Li, Xibo ; Peng, Mingli ; Raju, Paul Ananda ; Zhang, Qinlu ; Hu, Yue ; Jin, Yanyan ; Cui, Yali
Author_Institution :
Coll. of Life Sci., Northwest Univ., Xi´´an, China
Volume :
49
Issue :
1
fYear :
2013
fDate :
Jan. 2013
Firstpage :
359
Lastpage :
363
Abstract :
Dextran coated GoldMag nanoparticles (DGMNs) were synthesized, characterized and demonstrated to be effective vehicles for targeted drug delivery. Characterization of DGMNs by Fourier Transform Infrared Spectroscopy showed that their surface contained dextran whereas x-ray diffraction studies revealed that the particles were uniform with the expected crystalline structure. In thermo-gravimetric analysis studies, dextran accounted for 50% of the mass in the DGMN particles. DGMNs had an average diameter of 106 nm which can potentially prevent flocculation via steric stabilization. The blue shift of surface enhanced plasmon resonance absorption peaks observed during UV-Vis studies was indicative that DGMNs were colloidal-dispersed and uniform in size. Lastly, the dextran coating did not affect GoldMag particles´ inherent property of magnetism-saturation magnetization of DGMNs was efficient and fast-acting to external magnetic field (23.5 emu/g). In vitro drug studies showed that the cancer drug doxorubicin binds effectively to DGMNs and is steadily/controllably released from the particle surface in physiological conditions when compared to their parental GoldMag particles.
Keywords :
Fourier transform spectra; X-ray diffraction; absorption coefficients; biomedical materials; coating techniques; colloids; crystal structure; drug delivery systems; drugs; ferrites; flocculation; gold; infrared spectra; magnetic particles; magnetisation; nanofabrication; nanomedicine; nanoparticles; organic compounds; spectral line shift; surface plasmon resonance; thermal analysis; ultraviolet spectra; visible spectra; DGMN particles; Fe3O4-Au; Fourier transform infrared spectroscopy; UV-vis spectra; X-ray diffraction; blue shift; cancer drug doxorubicin; colloidal stability; colloidal-dispersed size; controlled-release; crystalline structure; dextran coated gold magnetite nanoparticles; external magnetic field; flocculation; particle surface; physiological conditions; saturation magnetization; size 106 nm; steric stabilization; surface contained dextran; surface enhanced plasmon resonance absorption peaks; targeted drug delivery; thermogravimetric analysis; Drugs; Gold; Iron; Magnetic cores; Magnetic resonance imaging; Nanoparticles; Saturation magnetization; Characterization; GoldMag nanoparticles; dextran; modification;
fLanguage :
English
Journal_Title :
Magnetics, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9464
Type :
jour
DOI :
10.1109/TMAG.2012.2224323
Filename :
6392357
Link To Document :
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