Magnetically Vectored Delivery of Cancer Drug Using Remotely On–Off Switchable NanoCapsules

Hollow-sphere-structured magnetic nanocapsules containing intentionally trapped iron oxide nanoparticles and anticancer drugs have been prepared to provide a powerful magnetic vector under moderate gradient magnetic fields. It is shown that these nanocapsules can penetrate into the interior of tumors and allow a controlled on-off switchable release of the anticancer drug cargo via remote 100 KHz RF field. This smart drug delivery system is nanoscale compact, with the drug molecules and magnetic nanoparticles contained within the hollow capsules having ~ 80 ~ 150nm diameter. In vitro results using a mouse model indicate that such a nanocapsule-mediated, on-demand drug release is effective in reducing tumor cell growth.