Title :
Molecular dynamics simulations of EM fields acting on SOD enzyme
Author :
Marracino, P. ; Paffi, A. ; Liberti, M. ; d´Inzeo, G. ; Apollonio, F.
Author_Institution :
Dept. of Inf. Eng., Electron. & Telecommun., Sapienza Univ. of Rome, Rome, Italy
Abstract :
Endogenous and exogenous perturbations acting on a protein can alter the thermodynamic equilibrium of the system, leading to a transition toward a denaturated state. In this paper we show results from molecular dynamics (MD) simulations of the superoxide dismutase (SOD) in water exposed to CW 1 GHz and 2.45 GHz signals, looking at the possible ways in which an external signal can be transduced into biochemical effects.
Keywords :
biochemistry; enzymes; molecular biophysics; molecular dynamics method; water; EM fields; SOD enzyme; biochemical effects; denaturated state; endogenous perturbations; exogenous perturbations; frequency 1 GHz; frequency 2.45 GHz; molecular dynamics simulation; protein; superoxide dismutase; thermodynamic equilibrium; water; Biological system modeling; Electric fields; Microwave theory and techniques; Physiology; Proteins; Spectrogram; CW signals; SOD enzyme; molecular dynamics;
Conference_Titel :
Microwave Conference (EuMC), 2014 44th European
Conference_Location :
Rome
DOI :
10.1109/EuMC.2014.6986555
