Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes

Author

Terrell, Thomas R. ; Bostick, Roberd ; Rogers, Gary L. ; Langston, Michael A. ; Barth, Jeffery ; Bennett, Ellen ; Sloane, Richard ; Galloway, Leslie ; Cantu, Robert C. ; Mihelic, F. Matthew

Author_Institution

Dept. of Family Med., Univ. of Tennessee Grad. Sch. of Med. (UTGSOM), Knoxville, TN, USA

fYear

2014

fDate

6-8 May 2014

Firstpage

1

Lastpage

4

Abstract

The management of sports concussion and an understanding of its risk factors are major foci in the literature on athletic injury. Although there is known influence of some genetic polymorphisms (GPs), such as APOE and the APOE promoter, on traumatic brain injury (TBI) outcome in non-athletic populations, very little work has focused on the role these GPs may play in sports concussion. We completed a large (n=3274) multi-center prospective cohort study of college athletes to study possible associations between various GPs and prospectively occurring sports concussion. We found no significant relationship between the APOE e4 allele, the APOE G-219T promoter, the tau exon 6 Ser53pro or the tau His47Tyr GPs on prospective concussion. Additional study of other GPs and haplotype combinations is a next logical step in the search for genetic predisposition to sports-related concussion.

Keywords

brain; genetics; injuries; molecular biophysics; polymorphism; proteins; sport; APOE G-219T promoter; APOE association; APOE e4 allele; APOE promoter; athletic injury; college athletes; genetic polymorphisms; genetic predisposition; haplotype combinations; multicenter prospective cohort; nonathletic populations; prospective cohort study; prospective concussion risk; sports concussion management; tau His47Tyr GPs; tau exon 6 Ser53pro; traumatic brain injury; Brain injuries; Educational institutions; Genetics; Sociology; Statistics; Testing; APOE; genetic polymorphisms; prospective cohort study; sports concussion;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Science and Engineering Center Conference (BSEC), 2014 Annual Oak Ridge National Laboratory

Conference_Location

Oak Ridge, TN

Type

conf

DOI

10.1109/BSEC.2014.6867745

Filename

6867745