Title :
Quantitative analysis of brain SPECT with 99mTc-HMPAO in patients with mild cognitive changes
Author :
Nikolov, N.A. ; Zalisna, Yu.D. ; Makeyev, S.S. ; Loshickij, P.P. ; Yaroshenko, O.Yu. ; Supruniuk, D.A.
Author_Institution :
Dept. of Phys. & Biomed. Electron., Nat. Tech. Univ. of Ukraine “KPI”, Kiev, Ukraine
Abstract :
Mild cognitive disorders in patients is often not accompanied by focal changes in brain regions, which significantly complicates the objective assessment of pathology. Therefore, a new approach of quantitative analysis of brain single-photon emission computed tomography is developed. The analysis is based on calculating the average gradient of radioactivity distribution in a brain cross-section along a predetermined direction, as well as on Fourier spectra analysis, which are characterized by "1/f" (flicker noise) type behavior. Pilot clinical study of six patients shows promising prospects of the developed method.
Keywords :
Fourier analysis; brain; cognition; flicker noise; medical disorders; single photon emission computed tomography; technetium; 1/f flicker noise-type behavior; 99mTc-HMPAO; Fourier spectra analysis; average gradient calculation; brain SPECT; brain regions; brain single-photon emission computed tomography; mild cognitive disorders; objective pathology assessment; quantitative analysis; radioactivity distribution; 1f noise; Conferences; Diseases; Lesions; Linear approximation; Single photon emission computed tomography; Synchronization; SPECT; brain; cognitive disorders; homeostasis; quantitative analysis of image; sinhronization;
Conference_Titel :
Electronics and Nanotechnology (ELNANO), 2014 IEEE 34th International Conference on
Conference_Location :
Kyiv
Print_ISBN :
978-1-4799-4581-8
DOI :
10.1109/ELNANO.2014.6873455
