Title :
The effect of the inhomogeneous magnetic fields on the antitumor activity of magnetic nanotherapy
Author :
Orel, V.E. ; Dzyatkovskaya, N.N. ; Kruchkov, E.I. ; Nikolov, N.A. ; Rykhalskiy, A.Y. ; Romanov, A.V. ; Penievskyi, M.I. ; Radaguz, A.V.
Author_Institution :
Med. Phys. & Bioeng. Dept., Nat. Cancer Inst., Kiev, Ukraine
Abstract :
In the research of animals with carcinosarcoma Walker-256 was shown, that magnetic nanocomplex on the basis of nanoparticles of Fe3O4 with antitumor anthracycline row antibiotic doxorubicin and next local electromagnetic irradiation by spatially inhomogeneous constant magnetic and variable electromagnetic fields had nonlinear effect on growth tumor volume in the direction of strengthening and inhibition tumor size. The radio frequency mild hyperthermia and magneto-sensitive nanocomplex increased antitumor effect up to 16% as compared to conventional doxorubicin.
Keywords :
antibacterial activity; hyperthermia; iron compounds; nanomagnetics; nanomedicine; nanoparticles; patient treatment; tumours; Fe3O4; Fe3O4 nanoparticles; antitumor activity; antitumor anthracycline row antibiotic doxorubicin; carcinosarcoma Walker-256; inhibition tumor size; inhomogeneous magnetic field effect; local electromagnetic irradiation; magnetic nanocomplex; magnetic nanotherapy; magnetosensitive nanocomplex; nonlinear effect; radiofrequency mild hyperthermia; spatially inhomogeneous constant magnetic fields; spatially inhomogeneous variable electromagnetic fields; tumor size strengthening; tumor volume growth; Cancer; Magnetic fields; Magnetic flux; Magnetomechanical effects; Nanoparticles; Saturation magnetization; Tumors; magnetic field; magnetic nanocomplex; magnetic-dipole applicator; tumor;
Conference_Titel :
Electronics and Nanotechnology (ELNANO), 2014 IEEE 34th International Conference on
Conference_Location :
Kyiv
Print_ISBN :
978-1-4799-4581-8
DOI :
10.1109/ELNANO.2014.6873909
