Title :
Label-free biosensor for detection of specific protein based on carbon nanotubes network thin film transistor
Author :
Lamberti, P. ; Mousavi, Seyedmohammad A. ; Tucci, V. ; Wagner, V.
Author_Institution :
Dept. of Inform. Eng., Electr. Eng. & Appl. Math. - DIEM -, Univ. of Salerno, Fisciano, Italy
Abstract :
A proof of concept of a thin film transistor (TFT) based on network of 99% semiconducting single walled carbon nanotubes (SWCNTs) is fabricated to show its applicability as a low cost biosensor for detecting specific molecules. The binding of biotin and streptavidin is used as a research model for evaluating sensor effectiveness. The biosensor response is based on the current modulation through interaction of biotinylated-SWCNTs in the channel of TFT structure with streptavidin. The proposed biosensor, whose fabrication process is carried out at room temperature, shows a successful immobilization of streptavidin with sensitivity detection as low as 100 pM. This new biosensor provides great potential for label-free detection of a wide range of biomolecules in applications such as array based screening.
Keywords :
biosensors; molecular biophysics; nanobiotechnology; nanosensors; proteins; semiconductor nanotubes; single-wall carbon nanotubes; thin film sensors; thin film transistors; C; TFT structure; array-based screening; biomolecules; biotin-streptavidin binding; biotinylated-SWCNT interaction; carbon nanotube network thin film transistor; label-free biosensor; semiconducting single walled carbon nanotubes; sensitivity detection; specific molecule detection; specific protein detection; Biosensors; Carbon; Carbon nanotubes; Nanobioscience; Probes; CNT; TFT; modeling; nanobiosensor;
Conference_Titel :
Nanotechnology Materials and Devices Conference (NMDC), 2014 IEEE 9th
Conference_Location :
Aci Castello
DOI :
10.1109/NMDC.2014.6997442
