A novel piezoelectric immunosensor for early cervical cancer detection

Cervical cancer is the most common cancer among worldwide women. The initial cervical screening of cervical lesion is very important. In this study, a novel method for early cervical cancer detection based on piezoelectric immunosensor was proposed. The method proposed in this paper involved short analyzing time for p16^INK4a detection, a protein that has been linked to cervical cancer. p16^INK4a antibody was dripped on the center of the AT-cut crystal and supernatant from different clinical sample was also dripped on the center of crystal, Absorb of the p16^INK4a by antibody caused a shift in the resonant frequency of the immunosensor and the resonant frequency was correlated to the amount of the p16^INK4a in supernatant. This method can be a promising assay for the initial screening of cervical lesion.