Proarrhythmic effects of cisapride: Insights from a simulation study

Author

Yongfeng Yuan ; Songjun Xie ; Kuanquan Wang ; Henggui Zhang

Author_Institution

Sch. of Comput. Sci. & Technol., Harbin Inst. of Technol., Harbin, China

fYear

2014

fDate

2-5 Nov. 2014

Firstpage

44

Lastpage

47

Abstract

Cisapride as a prokinetic drug inhibits rapid delayed rectifier potassium channel current. As producing QT interval prolongation and causes fatal cardiac arrhythmias, it has been withdrawn from clinical uses. However, exact mechanisms for the proarrhythmic effects of cisapride are incompletely unclear. In this study, we implemented a biophysically detailed computational model of the heart to quantify the effects of the cisapride on cardiac electrical activities at cellular and tissue levels, from which we analyzed the proarrhythmic effects of the agent.

Keywords

diseases; drugs; electrocardiography; QT interval prolongation; cardiac electrical activity; cellular level; cisapride; fatal cardiac arrhythmias; heart; potassium channel current; proarrhythmic effects; prokinetic drug; rapid delayed rectifier; tissue level; Biological system modeling; Computational modeling; Drugs; Electric potential; Electrocardiography; Heart; Mathematical model; cisapride; computational model; drug safety assessment;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedicine (BIBM), 2014 IEEE International Conference on

Conference_Location

Belfast

Type

conf

DOI

10.1109/BIBM.2014.6999258

Filename

6999258