Title :
Applying bioinformatic technique to discovery molecular mechansim of Banxia and Tianma combination treating tinnitus
Author :
Shanshan Shen ; Yaoxian Wang ; Guang Zheng ; Xiaojuan He ; Yong Tan ; Ke Zhou ; Dongmei Jia ; Aiping Lu ; Miao Jiang
Author_Institution :
Inst. of Basic Res. in Clinical Med., China Acad. of Chinese Med. Sci., Beijing, China
Abstract :
Tinnitus is the most common medical symptom that can be debilitating. Chinese herbal medicines (CHMs) play important roles in tinnitus treatment. This study analyzed the most frequently prescribed herbs used to treat tinnitus and the molecular mechanisms of therapeutic effects of these CHMs by text mining and bioinformatics technique. Results showed that pinellia ternate (Banxia) and gastrodin (Tianma) are the most frequently prescribed CHMs for treatment tinnitus. The molecular mechanisms of therapeutic effects of two CHMs were focused on sertoli cell-sertoli cell juntion signaling and NRF2-mediated oxidative stress response signaling. Integrative text mining and bioinformatics analysis may be a promising approach to find new drug and decipher their molecular mechanism intuitively.
Keywords :
bioinformatics; cellular biophysics; data mining; diseases; drugs; molecular biophysics; patient treatment; Chinese herbal medicines; NRF2-mediated oxidative stress response signaling; bioinformatic technique; drug; gastrodin; integrative text mining; molecular mechanisms; molecular mechansim; pinellia ternate; sertoli cell-sertoli cell juntion signaling; therapeutic effects; tinnitus treatment; Bioinformatics; Databases; Educational institutions; Image color analysis; Proteins; Stress; Text mining; bioinformatic technique; gastrodin (Tianma); pinellia ternate(Banxia); tinnitus;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2014 IEEE International Conference on
Conference_Location :
Belfast
DOI :
10.1109/BIBM.2014.6999348
