Title :
Generation of rotational flow in microfluidics device for formation of spheroid
Author :
Kojima, Masaru ; Horade, Mitsuhiro ; Takai, Hirochika ; Ohara, Kenichi ; Tanikawa, Tamio ; Kamiyama, Kazuto ; Mae, Yasushi ; Arai, Tamio
Author_Institution :
Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan
Abstract :
Spheroid is formed by making it agitate and circle in cell suspension. However, the injection of the cells used as pieces of spheroids, the recovery at the time of tissue formation, exchange of a culture medium, etc. are performed manually, and it is hard to say that efficient organization construction is performed. Thus, we suggest utility and possibility of applying microfluidics for formation of toroidal-like spheroid. Microfluidic devices to generate rotational flow were fabricated, and we conducted experiments using mouse embryo fibroblast cell.
Keywords :
bioMEMS; biological tissues; biomedical equipment; cellular biophysics; microfluidics; rotational flow; suspensions; cell injection; cell suspension; microfluidics device; mouse embryo fibroblast cell; rotational flow; tissue formation; toroidal-like spheroid formation;
Conference_Titel :
Micro-NanoMechatronics and Human Science (MHS), 2014 International Symposium on
Conference_Location :
Nagoya
Print_ISBN :
978-1-4799-6678-3
DOI :
10.1109/MHS.2014.7006134