Title :
Quantitative autofluorescence in retinal disease
Author :
Matet, A. ; Mohand-Said, S. ; Sahel, J.A. ; Paques, M. ; Rossant, F. ; Audo, I.
Author_Institution :
INSERM-DHOS, DHU ViewMaintain, Paris, France
Abstract :
Fundus autofluorescence (AF) is a retinal imaging modality based on the emission of light by the retina after stimulation at specific wavelengths, either 488 nm (blue autofluorescence, BAF) or 787 nm (near-infrared autofluorescence IRAF). The objective of this work was to describe and determine the feasibility of a methodology for quantitative AF visualization. Based on relative, normalized, gray intensity measures along concentric semi-circles in the nasal and temporal sides of the macula, it provided a combined graphical representation of quantitative BAF and IRAF curves. This method was applied to 8 healthy subjects and 9 cases of achromatopsia, a stationary congenital syndrome of cone photoreceptor dysfunction. Quantitative autofluorescence curves clearly identified a normal pattern in healthy subjects and two different abnormal patterns among the achromatopsia patients, that correlated to existing disease classifications based on retinal morphology assessed by optical coherence tomography.
Keywords :
biomedical optical imaging; colour vision; diseases; eye; fluorescence; medical image processing; optical tomography; vision defects; achromatopsia patient; blue autofluorescence; combined graphical representation; concentric semicircle; cone photoreceptor dysfunction; disease classification; fundus autofluorescence; gray intensity; light emission; macula nasal side; macula temporal side; near-infrared autofluorescence; optical coherence tomography; quantitative AF visualization; quantitative BAF curve; quantitative IRAF curve; quantitative autofluorescence curve; quantitative autofluorescence visualization; retinal disease; retinal imaging modality; retinal morphology; stationary congenital syndrome; wavelength 488 nm; wavelength 787 nm; Coherence; Diseases; Optical imaging; Photoreceptors; Retina; Visualization; Autofluorescence; Imaging; Near-infrared; Retina; Short-wave;
Conference_Titel :
Computational Intelligence for Multimedia Understanding (IWCIM), 2014 International Workshop on
Conference_Location :
Paris
DOI :
10.1109/IWCIM.2014.7008799